Van de Ven Brace Ends The Toffees' Run at Brand New Home Ground
The Dutch defender became the initial backline player to net two goals in a Premier League game for Tottenham since the Belgian defender in March 2013.
Key points
The Spurs defender heads into the net twice in opening period
Everton's Jake O'Brien has goal disallowed after VAR review
Senegalese midfielder nets third in dying moments
The defeat is Everton's initial at Hill Dickinson Stadium
Micky van de Ven scored twice as Spurs extended their winning streak in away games in the top division and delivered the Toffees their initial loss at their new home.
Everton were undefeated in their five previous fixtures at their new ground at the dockside location, having left Goodison Park behind after more than a century at the conclusion of the previous campaign.
But Tottenham's leader the Dutchman struck twice from set-pieces in the first half to put their impressive record at risk, and they were failed to mount a comeback before Pape Matar Sarr - set up by ex-Everton forward Richarlison - headed home a third to put the game to bed.
The Everton defender believed he had equalized the scores a short while after Van de Ven's first goal, directing a powerful header past the Spurs keeper from an Everton corner.
Beto, in the meantime, missed a number of opportunities, while Vicario made a series of fine saves to ensure the London club went five matches on the road without defeat in the Premier League.
But the VAR intervened, instructing Craig Pawson to check the goal on the pitchside monitor and the referee decided that Jack Grealish and Iliman Ndiaye were in an illegal position and had interfered with the Tottenham goalkeeper.
The win moves Thomas Frank's team into third place in the division, a handful of points off north London rivals and table-toppers the Gunners.
Everton remain in 14th position and sit six points ahead of the drop zone.
Tottenham analysis: The defender excels in duties at both ends of pitch
After a drab midweek performance in the European competition against the French side, where they managed a mere attempts on goal, Frank chose Randal Kolo Muani up front instead of ex-Everton forward the Brazilian.
The new arrival was failed to make much of an impact before being replaced for Richarlison after an hour on the field, but it emerged he proved unnecessary in the final outcome.
Centre-back the Dutchman transformed into an offensive threat to be reckoned with.
Tottenham's first goal came from a cleverly executed set-piece play, with the midfielder directing the ball toward the six-yard box for an unmarked the defender to head home.
And the captain - filling in as captain in Cristian Romero's absence - added his second in first-half stoppage time as he rose above the England keeper to nod in.
The Dutchman was just as impressive in defensive duties, partnering well with Kevin Danso as the pair dealt superbly with the 34 crosses thrown their way by the opposition.
Everton analysis: Toffees lacking striker's instinct
Everton's new home had been a happy hunting ground, but it appears the freshness may have faded somewhat and supporters headed to the gates after Sarr's final goal for Tottenham.
The break in the team's winning streak at home won't be a major concern for David Moyes, but their striker situation are.
The forward and Thierno Barry - the Toffees' two established strikers - had netted only a single goal combined before the weekend's outing.
And they were unable to add to that poor tally on a damp and dreary evening on in Liverpool.
The striker's form was epitomized when he chose to bicycle-kick a golden opportunity from close range, despite having room and time to reposition for a simpler shot that would have challenged Vicario.
The substitute, too, was unable to influence the game after replacing Beto in the second half.
It was not for a lack of chance. The majority of the home side's attacks came through the winger and the forward, who relentlessly whipped threatening balls into the Spurs penalty area.
Upcoming fixtures for both teams?
The Toffees: Moyes' men travel to Sunderland in the top flight on early November at 20:00 GMT.
Spurs: The London club travel to Newcastle's ground on Wednesday, 29 October for their next round Carabao Cup match against the Magpies.